Zagam is a fluoroquinolone antibiotic used in the treatment of bacterial infections. Zagam is about 37- 45% bound to proteins in the blood . Purchase Zagam achieves a high degree of penetration into most tissues, except for the central nervous system.
The Zagam medication achieves high concentrations in respiratory and sinus tissues. Following an oral loading dose of 400 mg followed by 200 mg daily, mean concentrations of sparfloxacin (2.5 to 5 h after dosing) in bronchial mucosa, epithelial lining fluid and alveolar macrophages are 4.4 µg/g, 15.0 µg/ml and 53.7 µg/g, respectively. The Zagam tablets contain a synthetic broad-spectrum antimicrobial agent for oral administration. Zagam, an aminodifluoroquinolone, is 5-Amino-1-cyclopropyl-7-(cis -3, 5-dimethyl-1-piperazinyl)-6, 8-difluoro-1, 4-dihydro-4-oxo-3-quinolinecarboxylic acid. Its empirical formula is C 19 H 22 F 2 N 4 O 3.Zagam achieves concentrations in bile and gallbladder of 7.1- to 83-fold the concurrent serum levels. In rabbits, Zagam achieves very good penetration into the ocular vitreous (54%), cornea (76%) and lens (36%) (Cochereau-Massin et at., 1993).Zagam like other Quinolones and fluoroquinolones, are bactericidal drugs, actively killing bacteria.
The Zagam must be taken exactly as directed by your doctor. If they do not understand these instructions, asks their pharmacist, nurse, or doctor to explain Zagam to them and also this antibiotic may be taken with or without food. The Zagam, like other Quinolones and fluoroquinolones, are bactericidal drugs, actively killing bacteria. Quinolones inhibit the bacterial DNA gyrase or the topoisomerase IV enzyme, thereby inhibiting DNA replication and transcription. Purchase Zagam has a molecular weight of 392.41. It occurs as a yellow crystalline powder. It is sparingly soluble in glacial acetic acid or chloroform, very slightly soluble in ethanol (95%), and practically insoluble in water and ether. It dissolves in dilute acetic acid or 0.1 N sodium hydroxide.
Zagam is available as a 200-mg round, white film-coated tablet. Each 200-mg tablet contains the following inactive ingredients: microcrystalline cellulose NF, corn starch NF, L-hydroxypropylcellulose NF, magnesium stearate NF, and colloidal silicone dioxide NF.The film coating contains: methylhydroxypropylcellulose USP, polyethylene glycol 6000, and titanium dioxide USP.The suggested daily dose of zagam in patients with normal renal function is two 200-mg tablets taken on the first day as a loading dose.
Purchase Zagam is indicated for the treatment of adults (>/= 18 years of age) with the following infections caused by susceptible strains of the designated microorganisms. The recommended daily dose of Zagam in patients with normal renal function is two 200-mg tablets taken on the first day as a loading dose. The Zagam must be taken exactly as directed by your doctor. If they do not understand these instructions, asks their pharmacist, nurse, or doctor to explain Zagam to them and also this antibiotic may be taken with or without food. The Zagam, like other Quinolones and fluoroquinolones, are bactericidal drugs, actively killing bacteria. Quinolones inhibit the bacterial DNA gyrase or the topoisomerase IV enzyme, thereby inhibiting DNA replication and transcription. Thereafter, one 200-mg tablet should be taken every 24 hours for a total of 10 days of therapy (11 tablets).
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